Chelsea are top of Group C after winning both of their games, and are poised to open up a five-point lead with another victory on Wednesday.
Having won 21 of their last 25 group games at home, the Blues are great value to do so.
Roma were beaten by Napoli at the weekend, and have managed two draws and six defeats from their previous eight matches on English soil.
Chelsea (-1) – 13/10
When Chelsea capitulated in the Premier League two years ago, they reserved their best football for the Champions League.
They should, therefore, beat Roma, who have not enjoyed a particular impressive start to the competition.
Daniele De Rossi to be booked – 2/1
De Rossi was booked against Napoli on Saturday, and is a good price to suffer the same fate in this one.
Pedro to score – 21/10
Having been left on the bench at Crystal Palace on Saturday, Pedro is a sure starter and a good bet to get his second Champions League goal of the season.
Image Credit: By Jason Bagley from Cape Town, South Africa – First pic from inside Stamford Bridge, CC BY-SA 2.0, https://commons.wikimedia.org/w/index.php?curid=12742963